Superior immune responses induced by intranasal immunization with recombinant adenovirus-based vaccine expressing full-length Spike protein of Middle East respiratory syndrome coronavirus
Identifieur interne : 000361 ( Main/Exploration ); précédent : 000360; suivant : 000362Superior immune responses induced by intranasal immunization with recombinant adenovirus-based vaccine expressing full-length Spike protein of Middle East respiratory syndrome coronavirus
Auteurs : Myung Hee Kim [Corée du Sud] ; Hyun Jik Kim [Corée du Sud] ; Jun Chang [Corée du Sud]Source :
- PLoS ONE [ 1932-6203 ] ; 2019.
Descripteurs français
- KwdFr :
- Adenoviridae (génétique), Adenoviridae (immunologie), Administration par voie nasale, Animaux, Anticorps neutralisants (immunologie), Cellules HEK293, Cellules cultivées, Coronavirus du syndrome respiratoire du Moyen-Orient (immunologie), Femelle, Glycoprotéine de spicule des coronavirus (génétique), Glycoprotéine de spicule des coronavirus (immunologie), Humains, Immunoglobuline A (immunologie), Infections à coronavirus (), Infections à coronavirus (immunologie), Souris, Souris de lignée BALB C, Spodoptera, Vaccination (), Vaccins synthétiques (génétique), Vaccins synthétiques (immunologie).
- MESH :
- génétique : Adenoviridae, Glycoprotéine de spicule des coronavirus, Vaccins synthétiques.
- immunologie : Adenoviridae, Anticorps neutralisants, Coronavirus du syndrome respiratoire du Moyen-Orient, Glycoprotéine de spicule des coronavirus, Immunoglobuline A, Infections à coronavirus, Vaccins synthétiques.
- Administration par voie nasale, Animaux, Cellules HEK293, Cellules cultivées, Femelle, Humains, Infections à coronavirus, Souris, Souris de lignée BALB C, Spodoptera, Vaccination.
English descriptors
- KwdEn :
- Adenoviridae (genetics), Adenoviridae (immunology), Administration, Intranasal, Animals, Antibodies, Neutralizing (immunology), Cells, Cultured, Coronavirus Infections (immunology), Coronavirus Infections (prevention & control), Female, HEK293 Cells, Humans, Immunoglobulin A (immunology), Mice, Mice, Inbred BALB C, Middle East Respiratory Syndrome Coronavirus (immunology), Spike Glycoprotein, Coronavirus (genetics), Spike Glycoprotein, Coronavirus (immunology), Spodoptera, Vaccination (methods), Vaccines, Synthetic (genetics), Vaccines, Synthetic (immunology).
- MESH :
- chemical , genetics : Spike Glycoprotein, Coronavirus, Vaccines, Synthetic.
- chemical , immunology : Antibodies, Neutralizing, Immunoglobulin A, Spike Glycoprotein, Coronavirus, Vaccines, Synthetic.
- genetics : Adenoviridae.
- immunology : Adenoviridae, Coronavirus Infections, Middle East Respiratory Syndrome Coronavirus.
- methods : Vaccination.
- prevention & control : Coronavirus Infections.
- Administration, Intranasal, Animals, Cells, Cultured, Female, HEK293 Cells, Humans, Mice, Mice, Inbred BALB C, Spodoptera.
Abstract
Middle East respiratory syndrome coronavirus (MERS-CoV) causes an acute and severe lower respiratory illness as well as vomiting, diarrhea, and renal failure. Because no licensed MERS-CoV vaccines are currently available, preventive and therapeutic measures are urgently needed. The surface spike (S) glycoprotein of MERS-CoV, which binds to the cellular receptor dipeptidyl peptidase 4 (DPP4), is considered as a major target for MERS-CoV vaccine development. Here, we designed recombinant replication-deficient adenovirus-based vaccines expressing the N-terminal domain (rAd/NTD) and receptor-binding domain (rAd/RBD) of the MERS-CoV S1 subunit and full-length Spike protein (rAd/Spike). We found that immunization with candidate vaccines via intranasal route induced S1-specific IgG antibodies and neutralizing antibodies against MERS spike pseudotyped virus. Especially, rAd/Spike induced the highest neutralizing antibody titer and the strongest cytokine-induced T cell responses among the three candidate vaccines. To compare the immune responses induced by different administration routes, rAd/Spike was administered via intranasal, sublingual, or intramuscular route. All these administration routes exhibited neutralizing effects in the serum. MERS-CoV-specific neutralizing IgA antibodies in the bronchoalveolar lavage fluid were only induced by intranasal and sublingual administration but not by intramuscular administration. Intranasal administration with rAd/Spike also created resident memory CD8 T cells in the airway and lung parenchyma. Taken together, our results showed that both the humoral and cellular immune responses are highly induced by rAd/Spike administration, suggesting that rAd/Spike may confer protection against MERS-CoV infection.
Url:
DOI: 10.1371/journal.pone.0220196
PubMed: 31329652
PubMed Central: 6645677
Affiliations:
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Le document en format XML
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sort="Kim, Myung Hee" uniqKey="Kim M" first="Myung Hee" last="Kim">Myung Hee Kim</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Graduate School of Pharmaceutical Sciences, Ewha Woman’s University, Seoul, Republic of Korea</addr-line></nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Graduate School of Pharmaceutical Sciences, Ewha Woman’s University, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Kim, Hyun Jik" sort="Kim, Hyun Jik" uniqKey="Kim H" first="Hyun Jik" last="Kim">Hyun Jik Kim</name><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>Department of Otorhinolaryngology, Seoul National University College of Medicine, Seoul, Republic of Korea</addr-line></nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Otorhinolaryngology, Seoul National University 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scheme="KwdEn" xml:lang="en"><term>Adenoviridae (genetics)</term><term>Adenoviridae (immunology)</term><term>Administration, Intranasal</term><term>Animals</term><term>Antibodies, Neutralizing (immunology)</term><term>Cells, Cultured</term><term>Coronavirus Infections (immunology)</term><term>Coronavirus Infections (prevention & control)</term><term>Female</term><term>HEK293 Cells</term><term>Humans</term><term>Immunoglobulin A (immunology)</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Middle East Respiratory Syndrome Coronavirus (immunology)</term><term>Spike Glycoprotein, Coronavirus (genetics)</term><term>Spike Glycoprotein, Coronavirus (immunology)</term><term>Spodoptera</term><term>Vaccination (methods)</term><term>Vaccines, Synthetic (genetics)</term><term>Vaccines, Synthetic (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adenoviridae (génétique)</term><term>Adenoviridae (immunologie)</term><term>Administration par voie nasale</term><term>Animaux</term><term>Anticorps neutralisants (immunologie)</term><term>Cellules HEK293</term><term>Cellules cultivées</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (immunologie)</term><term>Femelle</term><term>Glycoprotéine de spicule des coronavirus (génétique)</term><term>Glycoprotéine de spicule des coronavirus (immunologie)</term><term>Humains</term><term>Immunoglobuline A (immunologie)</term><term>Infections à coronavirus ()</term><term>Infections à coronavirus (immunologie)</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Spodoptera</term><term>Vaccination ()</term><term>Vaccins synthétiques (génétique)</term><term>Vaccins synthétiques (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Spike Glycoprotein, Coronavirus</term><term>Vaccines, Synthetic</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antibodies, Neutralizing</term><term>Immunoglobulin A</term><term>Spike Glycoprotein, Coronavirus</term><term>Vaccines, Synthetic</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Adenoviridae</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Adenoviridae</term><term>Glycoprotéine de spicule des coronavirus</term><term>Vaccins synthétiques</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Adenoviridae</term><term>Anticorps neutralisants</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Glycoprotéine de spicule des coronavirus</term><term>Immunoglobuline A</term><term>Infections à coronavirus</term><term>Vaccins synthétiques</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Adenoviridae</term><term>Coronavirus Infections</term><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Vaccination</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Administration, Intranasal</term><term>Animals</term><term>Cells, Cultured</term><term>Female</term><term>HEK293 Cells</term><term>Humans</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Spodoptera</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Administration par voie nasale</term><term>Animaux</term><term>Cellules HEK293</term><term>Cellules cultivées</term><term>Femelle</term><term>Humains</term><term>Infections à coronavirus</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Spodoptera</term><term>Vaccination</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Middle East respiratory syndrome coronavirus (MERS-CoV) causes an acute and severe lower respiratory illness as well as vomiting, diarrhea, and renal failure. Because no licensed MERS-CoV vaccines are currently available, preventive and therapeutic measures are urgently needed. The surface spike (S) glycoprotein of MERS-CoV, which binds to the cellular receptor dipeptidyl peptidase 4 (DPP4), is considered as a major target for MERS-CoV vaccine development. Here, we designed recombinant replication-deficient adenovirus-based vaccines expressing the N-terminal domain (rAd/NTD) and receptor-binding domain (rAd/RBD) of the MERS-CoV S1 subunit and full-length Spike protein (rAd/Spike). We found that immunization with candidate vaccines via intranasal route induced S1-specific IgG antibodies and neutralizing antibodies against MERS spike pseudotyped virus. Especially, rAd/Spike induced the highest neutralizing antibody titer and the strongest cytokine-induced T cell responses among the three candidate vaccines. To compare the immune responses induced by different administration routes, rAd/Spike was administered via intranasal, sublingual, or intramuscular route. All these administration routes exhibited neutralizing effects in the serum. MERS-CoV-specific neutralizing IgA antibodies in the bronchoalveolar lavage fluid were only induced by intranasal and sublingual administration but not by intramuscular administration. Intranasal administration with rAd/Spike also created resident memory CD8 T cells in the airway and lung parenchyma. Taken together, our results showed that both the humoral and cellular immune responses are highly induced by rAd/Spike administration, suggesting that rAd/Spike may confer protection against MERS-CoV infection.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Zaki, Am" uniqKey="Zaki A">AM Zaki</name></author><author><name sortKey="Van Boheemen, S" uniqKey="Van Boheemen S">S Van Boheemen</name></author><author><name sortKey="Bestebroer, Tm" uniqKey="Bestebroer T">TM Bestebroer</name></author><author><name sortKey="Osterhaus, Ad" uniqKey="Osterhaus A">AD Osterhaus</name></author><author><name sortKey="Fouchier, Ra" uniqKey="Fouchier R">RA Fouchier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bermingham, A" uniqKey="Bermingham A">A Bermingham</name></author><author><name sortKey="Chand, M" uniqKey="Chand M">M Chand</name></author><author><name sortKey="Brown, C" uniqKey="Brown C">C Brown</name></author><author><name sortKey="Aarons, E" uniqKey="Aarons E">E Aarons</name></author><author><name sortKey="Tong, C" uniqKey="Tong C">C Tong</name></author><author><name sortKey="Langrish, C" uniqKey="Langrish C">C Langrish</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guery, B" uniqKey="Guery B">B Guery</name></author><author><name sortKey="Poissy, J" uniqKey="Poissy J">J Poissy</name></author><author><name sortKey="El Mansouf, L" uniqKey="El Mansouf L">L el Mansouf</name></author><author><name sortKey="Sejourne, C" uniqKey="Sejourne C">C Séjourné</name></author><author><name sortKey="Ettahar, N" uniqKey="Ettahar N">N Ettahar</name></author><author><name sortKey="Lemaire, X" uniqKey="Lemaire X">X Lemaire</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mackay, Im" uniqKey="Mackay I">IM Mackay</name></author><author><name sortKey="Arden, Ke" uniqKey="Arden K">KE Arden</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alraddadi, Bm" uniqKey="Alraddadi B">BM Alraddadi</name></author><author><name sortKey="Watson, Jt" uniqKey="Watson J">JT Watson</name></author><author><name sortKey="Almarashi, A" uniqKey="Almarashi A">A Almarashi</name></author><author><name sortKey="Abedi, Gr" uniqKey="Abedi G">GR Abedi</name></author><author><name sortKey="Turkistani, A" uniqKey="Turkistani A">A Turkistani</name></author><author><name sortKey="Sadran, M" uniqKey="Sadran M">M Sadran</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Raj, Vs" uniqKey="Raj V">VS Raj</name></author><author><name sortKey="Osterhaus, Ad" uniqKey="Osterhaus A">AD Osterhaus</name></author><author><name sortKey="Fouchier, Ra" uniqKey="Fouchier R">RA Fouchier</name></author><author><name sortKey="Haagmans, Bl" uniqKey="Haagmans B">BL Haagmans</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zumla, A" uniqKey="Zumla A">A Zumla</name></author><author><name sortKey="Hui, Ds" uniqKey="Hui D">DS Hui</name></author><author><name sortKey="Perlman, S" uniqKey="Perlman S">S Perlman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cho, Sy" uniqKey="Cho S">SY Cho</name></author><author><name sortKey="Kang, J" uniqKey="Kang J">J Kang</name></author><author><name sortKey="Ha, Ye" uniqKey="Ha Y">YE Ha</name></author><author><name sortKey="Park, Ge" uniqKey="Park G">GE Park</name></author><author><name sortKey="Lee, Jy" uniqKey="Lee J">JY Lee</name></author><author><name sortKey="Ko, J" uniqKey="Ko J">J Ko</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Okba, Nm" uniqKey="Okba N">NM Okba</name></author><author><name sortKey="Raj, Vs" uniqKey="Raj V">VS Raj</name></author><author><name sortKey="Haagmans, Bl" uniqKey="Haagmans B">BL Haagmans</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Modjarrad, K" uniqKey="Modjarrad K">K Modjarrad</name></author><author><name sortKey="Moorthy, Vs" uniqKey="Moorthy V">VS Moorthy</name></author><author><name sortKey="Embarek, Pb" uniqKey="Embarek P">PB Embarek</name></author><author><name sortKey="Van Kerkhove, M" uniqKey="Van Kerkhove M">M Van Kerkhove</name></author><author><name sortKey="Kim, J" uniqKey="Kim J">J Kim</name></author><author><name sortKey="Kieny, M" uniqKey="Kieny M">M Kieny</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chan, Jf" uniqKey="Chan J">JF Chan</name></author><author><name sortKey="Lau, Sk" uniqKey="Lau S">SK Lau</name></author><author><name sortKey="To, Kk" uniqKey="To K">KK To</name></author><author><name sortKey="Cheng, Vc" uniqKey="Cheng V">VC Cheng</name></author><author><name sortKey="Woo, Pc" uniqKey="Woo P">PC Woo</name></author><author><name sortKey="Yuen, Ky" uniqKey="Yuen K">KY Yuen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Groot, Rj" uniqKey="De Groot R">RJ de Groot</name></author><author><name sortKey="Baker, Sc" uniqKey="Baker S">SC Baker</name></author><author><name sortKey="Baric, Rs" uniqKey="Baric R">RS Baric</name></author><author><name sortKey="Brown, Cs" uniqKey="Brown C">CS Brown</name></author><author><name sortKey="Drosten, C" uniqKey="Drosten C">C Drosten</name></author><author><name sortKey="Enjuanes, L" uniqKey="Enjuanes L">L Enjuanes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Durai, P" uniqKey="Durai P">P Durai</name></author><author><name sortKey="Batool, M" uniqKey="Batool M">M Batool</name></author><author><name sortKey="Shah, M" uniqKey="Shah M">M Shah</name></author><author><name sortKey="Choi, S" uniqKey="Choi S">S Choi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cotten, M" uniqKey="Cotten M">M Cotten</name></author><author><name sortKey="Lam, Tt" uniqKey="Lam T">TT Lam</name></author><author><name sortKey="Watson, Sj" uniqKey="Watson S">SJ Watson</name></author><author><name sortKey="Palser, Al" uniqKey="Palser A">AL Palser</name></author><author><name sortKey="Petrova, V" uniqKey="Petrova V">V Petrova</name></author><author><name sortKey="Grant, P" uniqKey="Grant P">P Grant</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Boheemen, S" uniqKey="Van Boheemen S">S van Boheemen</name></author><author><name sortKey="De Graaf, M" uniqKey="De Graaf M">M de Graaf</name></author><author><name sortKey="Lauber, C" uniqKey="Lauber C">C Lauber</name></author><author><name sortKey="Bestebroer, Tm" uniqKey="Bestebroer T">TM Bestebroer</name></author><author><name sortKey="Raj, Vs" uniqKey="Raj V">VS Raj</name></author><author><name sortKey="Zaki, Am" uniqKey="Zaki A">AM Zaki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lu, G" uniqKey="Lu G">G Lu</name></author><author><name sortKey="Hu, Y" uniqKey="Hu Y">Y Hu</name></author><author><name sortKey="Wang, Q" uniqKey="Wang Q">Q Wang</name></author><author><name sortKey="Qi, J" uniqKey="Qi J">J Qi</name></author><author><name sortKey="Gao, F" uniqKey="Gao F">F Gao</name></author><author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Raj, Vs" uniqKey="Raj V">VS Raj</name></author><author><name sortKey="Mou, H" uniqKey="Mou H">H Mou</name></author><author><name sortKey="Smits, Sl" uniqKey="Smits S">SL Smits</name></author><author><name sortKey="Dekkers, Dh" uniqKey="Dekkers D">DH Dekkers</name></author><author><name sortKey="Muller, Ma" uniqKey="Muller M">MA Müller</name></author><author><name sortKey="Dijkman, R" uniqKey="Dijkman R">R Dijkman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, N" uniqKey="Wang N">N Wang</name></author><author><name sortKey="Shi, X" uniqKey="Shi X">X Shi</name></author><author><name sortKey="Jiang, L" uniqKey="Jiang L">L Jiang</name></author><author><name sortKey="Zhang, S" uniqKey="Zhang S">S Zhang</name></author><author><name sortKey="Wang, D" uniqKey="Wang D">D Wang</name></author><author><name sortKey="Tong, P" uniqKey="Tong P">P Tong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Millet, Jk" uniqKey="Millet J">JK Millet</name></author><author><name sortKey="Whittaker, Gr" uniqKey="Whittaker G">GR Whittaker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weiss, Sr" uniqKey="Weiss S">SR Weiss</name></author><author><name sortKey="Navas Martin, S" uniqKey="Navas Martin S">S Navas-Martin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, Q" uniqKey="Wang Q">Q Wang</name></author><author><name sortKey="Wong, G" uniqKey="Wong G">G Wong</name></author><author><name sortKey="Lu, G" uniqKey="Lu G">G Lu</name></author><author><name sortKey="Yan, J" uniqKey="Yan J">J Yan</name></author><author><name sortKey="Gao, Gf" uniqKey="Gao G">GF Gao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Coleman, Cm" uniqKey="Coleman C">CM Coleman</name></author><author><name sortKey="Liu, Yv" uniqKey="Liu Y">YV Liu</name></author><author><name sortKey="Mu, H" uniqKey="Mu H">H Mu</name></author><author><name sortKey="Taylor, Jk" uniqKey="Taylor J">JK Taylor</name></author><author><name sortKey="Massare, M" uniqKey="Massare M">M Massare</name></author><author><name sortKey="Flyer, Dc" uniqKey="Flyer D">DC Flyer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Du, L" uniqKey="Du L">L Du</name></author><author><name sortKey="Yang, Y" uniqKey="Yang Y">Y Yang</name></author><author><name sortKey="Zhou, Y" uniqKey="Zhou Y">Y Zhou</name></author><author><name sortKey="Lu, L" uniqKey="Lu L">L Lu</name></author><author><name sortKey="Li, F" uniqKey="Li F">F Li</name></author><author><name sortKey="Jiang, S" uniqKey="Jiang S">S Jiang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Agrawal, As" uniqKey="Agrawal A">AS Agrawal</name></author><author><name sortKey="Tao, X" uniqKey="Tao X">X Tao</name></author><author><name sortKey="Algaissi, A" uniqKey="Algaissi A">A Algaissi</name></author><author><name sortKey="Garron, T" uniqKey="Garron T">T Garron</name></author><author><name sortKey="Narayanan, K" uniqKey="Narayanan K">K Narayanan</name></author><author><name sortKey="Peng, B" uniqKey="Peng B">B Peng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Du, L" uniqKey="Du L">L Du</name></author><author><name sortKey="Kou, Z" uniqKey="Kou Z">Z Kou</name></author><author><name sortKey="Ma, C" uniqKey="Ma C">C Ma</name></author><author><name sortKey="Tao, X" uniqKey="Tao X">X Tao</name></author><author><name sortKey="Wang, L" uniqKey="Wang L">L Wang</name></author><author><name sortKey="Zhao, G" uniqKey="Zhao G">G Zhao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jiaming, L" uniqKey="Jiaming L">L Jiaming</name></author><author><name sortKey="Yanfeng, Y" uniqKey="Yanfeng Y">Y Yanfeng</name></author><author><name sortKey="Yao, D" uniqKey="Yao D">D Yao</name></author><author><name sortKey="Yawei, H" uniqKey="Yawei H">H Yawei</name></author><author><name sortKey="Linlin, B" uniqKey="Linlin B">B Linlin</name></author><author><name sortKey="Baoying, H" uniqKey="Baoying H">H Baoying</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, L" uniqKey="Wang L">L Wang</name></author><author><name sortKey="Shi, W" uniqKey="Shi W">W Shi</name></author><author><name sortKey="Joyce, Mg" uniqKey="Joyce M">MG Joyce</name></author><author><name sortKey="Modjarrad, K" uniqKey="Modjarrad K">K Modjarrad</name></author><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name></author><author><name sortKey="Leung, K" uniqKey="Leung K">K Leung</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ma, C" uniqKey="Ma C">C Ma</name></author><author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name></author><author><name sortKey="Wang, L" uniqKey="Wang L">L Wang</name></author><author><name sortKey="Zhao, G" uniqKey="Zhao G">G Zhao</name></author><author><name sortKey="Tao, X" uniqKey="Tao X">X Tao</name></author><author><name sortKey="Tseng, Ck" uniqKey="Tseng C">CK Tseng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lan, J" uniqKey="Lan J">J Lan</name></author><author><name sortKey="Deng, Y" uniqKey="Deng Y">Y Deng</name></author><author><name sortKey="Chen, H" uniqKey="Chen H">H Chen</name></author><author><name sortKey="Lu, G" uniqKey="Lu G">G Lu</name></author><author><name sortKey="Wang, W" uniqKey="Wang W">W Wang</name></author><author><name sortKey="Guo, X" uniqKey="Guo X">X Guo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Muthumani, K" uniqKey="Muthumani K">K Muthumani</name></author><author><name sortKey="Falzarano, D" uniqKey="Falzarano D">D Falzarano</name></author><author><name sortKey="Reuschel, El" uniqKey="Reuschel E">EL Reuschel</name></author><author><name sortKey="Tingey, C" uniqKey="Tingey C">C Tingey</name></author><author><name sortKey="Flingai, S" uniqKey="Flingai S">S Flingai</name></author><author><name sortKey="Villarreal, Do" uniqKey="Villarreal D">DO Villarreal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Al Amri, Ss" uniqKey="Al Amri S">SS Al-Amri</name></author><author><name sortKey="Abbas, At" uniqKey="Abbas A">AT Abbas</name></author><author><name sortKey="Siddiq, La" uniqKey="Siddiq L">LA Siddiq</name></author><author><name sortKey="Alghamdi, A" uniqKey="Alghamdi A">A Alghamdi</name></author><author><name sortKey="Sanki, Ma" uniqKey="Sanki M">MA Sanki</name></author><author><name sortKey="Al Muhanna, Mk" uniqKey="Al Muhanna M">MK Al-Muhanna</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, E" uniqKey="Kim E">E Kim</name></author><author><name sortKey="Okada, K" uniqKey="Okada K">K Okada</name></author><author><name sortKey="Kenniston, T" uniqKey="Kenniston T">T Kenniston</name></author><author><name sortKey="Raj, Vs" uniqKey="Raj V">VS Raj</name></author><author><name sortKey="Alhajri, Mm" uniqKey="Alhajri M">MM AlHajri</name></author><author><name sortKey="Farag, Ea" uniqKey="Farag E">EA Farag</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guo, X" uniqKey="Guo X">X Guo</name></author><author><name sortKey="Deng, Y" uniqKey="Deng Y">Y Deng</name></author><author><name sortKey="Chen, H" uniqKey="Chen H">H Chen</name></author><author><name sortKey="Lan, J" uniqKey="Lan J">J Lan</name></author><author><name sortKey="Wang, W" uniqKey="Wang W">W Wang</name></author><author><name sortKey="Zou, X" uniqKey="Zou X">X Zou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Haagmans, Bl" uniqKey="Haagmans B">BL Haagmans</name></author><author><name sortKey="Van Den Brand, Jm" uniqKey="Van Den Brand J">JM van den Brand</name></author><author><name sortKey="Raj, Vs" uniqKey="Raj V">VS Raj</name></author><author><name sortKey="Volz, A" uniqKey="Volz A">A Volz</name></author><author><name sortKey="Wohlsein, P" uniqKey="Wohlsein P">P Wohlsein</name></author><author><name sortKey="Smits, Sl" uniqKey="Smits S">SL Smits</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Volz, A" uniqKey="Volz A">A Volz</name></author><author><name sortKey="Kupke, A" uniqKey="Kupke A">A Kupke</name></author><author><name sortKey="Song, F" uniqKey="Song F">F Song</name></author><author><name sortKey="Jany, S" uniqKey="Jany S">S Jany</name></author><author><name sortKey="Fux, R" uniqKey="Fux R">R Fux</name></author><author><name sortKey="Shams Eldin, H" uniqKey="Shams Eldin H">H Shams-Eldin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Song, F" uniqKey="Song F">F Song</name></author><author><name sortKey="Fux, R" uniqKey="Fux R">R Fux</name></author><author><name sortKey="Provacia, Lb" uniqKey="Provacia L">LB Provacia</name></author><author><name sortKey="Volz, A" uniqKey="Volz A">A Volz</name></author><author><name sortKey="Eickmann, M" uniqKey="Eickmann M">M Eickmann</name></author><author><name sortKey="Becker, S" uniqKey="Becker S">S Becker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lan, J" uniqKey="Lan J">J Lan</name></author><author><name sortKey="Yao, Y" uniqKey="Yao Y">Y Yao</name></author><author><name sortKey="Deng, Y" uniqKey="Deng Y">Y Deng</name></author><author><name sortKey="Chen, H" uniqKey="Chen H">H Chen</name></author><author><name sortKey="Lu, G" uniqKey="Lu G">G Lu</name></author><author><name sortKey="Wang, W" uniqKey="Wang W">W Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, L" uniqKey="Wang L">L Wang</name></author><author><name sortKey="Shi, W" uniqKey="Shi W">W Shi</name></author><author><name sortKey="Chappell, Jd" uniqKey="Chappell J">JD Chappell</name></author><author><name sortKey="Joyce, Mg" uniqKey="Joyce M">MG Joyce</name></author><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name></author><author><name sortKey="Kanekiyo, M" uniqKey="Kanekiyo M">M Kanekiyo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Park, Dy" uniqKey="Park D">DY Park</name></author><author><name sortKey="Kim, S" uniqKey="Kim S">S Kim</name></author><author><name sortKey="Kim, C" uniqKey="Kim C">C Kim</name></author><author><name sortKey="Yoon, J" uniqKey="Yoon J">J Yoon</name></author><author><name sortKey="Kim, H" uniqKey="Kim H">H Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="He, Tc" uniqKey="He T">TC He</name></author><author><name sortKey="Zhou, S" uniqKey="Zhou S">S Zhou</name></author><author><name sortKey="Da Costa, Lt" uniqKey="Da Costa L">LT da Costa</name></author><author><name sortKey="Yu, J" uniqKey="Yu J">J Yu</name></author><author><name sortKey="Kinzler, Kw" uniqKey="Kinzler K">KW Kinzler</name></author><author><name sortKey="Vogelstein, B" uniqKey="Vogelstein B">B Vogelstein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, Mh" uniqKey="Kim M">MH Kim</name></author><author><name sortKey="Kang, J" uniqKey="Kang J">J Kang</name></author><author><name sortKey="Kim, J" uniqKey="Kim J">J Kim</name></author><author><name sortKey="Jung, He" uniqKey="Jung H">HE Jung</name></author><author><name sortKey="Lee, Hk" uniqKey="Lee H">HK Lee</name></author><author><name sortKey="Chang, J" uniqKey="Chang J">J Chang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yuan, Y" uniqKey="Yuan Y">Y Yuan</name></author><author><name sortKey="Cao, D" uniqKey="Cao D">D Cao</name></author><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name></author><author><name sortKey="Ma, J" uniqKey="Ma J">J Ma</name></author><author><name sortKey="Qi, J" uniqKey="Qi J">J Qi</name></author><author><name sortKey="Wang, Q" uniqKey="Wang Q">Q Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Qian, Z" uniqKey="Qian Z">Z Qian</name></author><author><name sortKey="Dominguez, Sr" uniqKey="Dominguez S">SR Dominguez</name></author><author><name sortKey="Holmes, Kv" uniqKey="Holmes K">KV Holmes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hossler, P" uniqKey="Hossler P">P. Hossler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brandtzaeg, P" uniqKey="Brandtzaeg P">P. Brandtzaeg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhao, J" uniqKey="Zhao J">J Zhao</name></author><author><name sortKey="Li, K" uniqKey="Li K">K Li</name></author><author><name sortKey="Wohlford Lenane, C" uniqKey="Wohlford Lenane C">C Wohlford-Lenane</name></author><author><name sortKey="Agnihothram, Ss" uniqKey="Agnihothram S">SS Agnihothram</name></author><author><name sortKey="Fett, C" uniqKey="Fett C">C Fett</name></author><author><name sortKey="Zhao, J" uniqKey="Zhao J">J Zhao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, Wj" uniqKey="Liu W">WJ Liu</name></author><author><name sortKey="Lan, J" uniqKey="Lan J">J Lan</name></author><author><name sortKey="Liu, K" uniqKey="Liu K">K Liu</name></author><author><name sortKey="Deng, Y" uniqKey="Deng Y">Y Deng</name></author><author><name sortKey="Yao, Y" uniqKey="Yao Y">Y Yao</name></author><author><name sortKey="Wu, S" uniqKey="Wu S">S Wu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, Y" uniqKey="Chen Y">Y Chen</name></author><author><name sortKey="Lu, S" uniqKey="Lu S">S Lu</name></author><author><name sortKey="Jia, H" uniqKey="Jia H">H Jia</name></author><author><name sortKey="Deng, Y" uniqKey="Deng Y">Y Deng</name></author><author><name sortKey="Zhou, J" uniqKey="Zhou J">J Zhou</name></author><author><name sortKey="Huang, B" uniqKey="Huang B">B Huang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mcmaster, Sr" uniqKey="Mcmaster S">SR McMaster</name></author><author><name sortKey="Wein, An" uniqKey="Wein A">AN Wein</name></author><author><name sortKey="Dunbar, Pr" uniqKey="Dunbar P">PR Dunbar</name></author><author><name sortKey="Hayward, Sl" uniqKey="Hayward S">SL Hayward</name></author><author><name sortKey="Cartwright, Ek" uniqKey="Cartwright E">EK Cartwright</name></author><author><name sortKey="Denning, Tl" uniqKey="Denning T">TL Denning</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mcmaster, Sr" uniqKey="Mcmaster S">SR McMaster</name></author><author><name sortKey="Wilson, Jj" uniqKey="Wilson J">JJ Wilson</name></author><author><name sortKey="Wang, H" uniqKey="Wang H">H Wang</name></author><author><name sortKey="Kohlmeier, Je" uniqKey="Kohlmeier J">JE Kohlmeier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Takamura, S" uniqKey="Takamura S">S Takamura</name></author><author><name sortKey="Roberts, Ad" uniqKey="Roberts A">AD Roberts</name></author><author><name sortKey="Jelley Gibbs, Dm" uniqKey="Jelley Gibbs D">DM Jelley-Gibbs</name></author><author><name sortKey="Wittmer, St" uniqKey="Wittmer S">ST Wittmer</name></author><author><name sortKey="Kohlmeier, Je" uniqKey="Kohlmeier J">JE Kohlmeier</name></author><author><name sortKey="Woodland, Dl" uniqKey="Woodland D">DL Woodland</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Anderson, Kg" uniqKey="Anderson K">KG Anderson</name></author><author><name sortKey="Mayer Barber, K" uniqKey="Mayer Barber K">K Mayer-Barber</name></author><author><name sortKey="Sung, H" uniqKey="Sung H">H Sung</name></author><author><name sortKey="Beura, L" uniqKey="Beura L">L Beura</name></author><author><name sortKey="James, Br" uniqKey="James B">BR James</name></author><author><name sortKey="Taylor, Jj" uniqKey="Taylor J">JJ Taylor</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wu, T" uniqKey="Wu T">T Wu</name></author><author><name sortKey="Hu, Y" uniqKey="Hu Y">Y Hu</name></author><author><name sortKey="Lee, Yt" uniqKey="Lee Y">YT Lee</name></author><author><name sortKey="Bouchard, Kr" uniqKey="Bouchard K">KR Bouchard</name></author><author><name sortKey="Benechet, A" uniqKey="Benechet A">A Benechet</name></author><author><name sortKey="Khanna, K" uniqKey="Khanna K">K Khanna</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Siegrist, C" uniqKey="Siegrist C">C. Siegrist</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Coleman, Cm" uniqKey="Coleman C">CM Coleman</name></author><author><name sortKey="Frieman, Mb" uniqKey="Frieman M">MB Frieman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chi, H" uniqKey="Chi H">H Chi</name></author><author><name sortKey="Zheng, X" uniqKey="Zheng X">X Zheng</name></author><author><name sortKey="Wang, X" uniqKey="Wang X">X Wang</name></author><author><name sortKey="Wang, C" uniqKey="Wang C">C Wang</name></author><author><name sortKey="Wang, H" uniqKey="Wang H">H Wang</name></author><author><name sortKey="Gai, W" uniqKey="Gai W">W Gai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Modjarrad, K" uniqKey="Modjarrad K">K. Modjarrad</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, Yj" uniqKey="Kim Y">YJ Kim</name></author><author><name sortKey="Cho, Yj" uniqKey="Cho Y">YJ Cho</name></author><author><name sortKey="Kim, Dw" uniqKey="Kim D">DW Kim</name></author><author><name sortKey="Yang, Js" uniqKey="Yang J">JS Yang</name></author><author><name sortKey="Kim, H" uniqKey="Kim H">H Kim</name></author><author><name sortKey="Park, S" uniqKey="Park S">S Park</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kleine Weber, H" uniqKey="Kleine Weber H">H Kleine-Weber</name></author><author><name sortKey="Elzayat, Mt" uniqKey="Elzayat M">MT Elzayat</name></author><author><name sortKey="Wang, L" uniqKey="Wang L">L Wang</name></author><author><name sortKey="Graham, Bs" uniqKey="Graham B">BS Graham</name></author><author><name sortKey="Muller, Ma" uniqKey="Muller M">MA Muller</name></author><author><name sortKey="Drosten, C" uniqKey="Drosten C">C Drosten</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sui, J" uniqKey="Sui J">J Sui</name></author><author><name sortKey="Deming, M" uniqKey="Deming M">M Deming</name></author><author><name sortKey="Rockx, B" uniqKey="Rockx B">B Rockx</name></author><author><name sortKey="Liddington, Rc" uniqKey="Liddington R">RC Liddington</name></author><author><name sortKey="Zhu, Qk" uniqKey="Zhu Q">QK Zhu</name></author><author><name sortKey="Baric, Rs" uniqKey="Baric R">RS Baric</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, Y" uniqKey="Yang Y">Y Yang</name></author><author><name sortKey="Deng, Y" uniqKey="Deng Y">Y Deng</name></author><author><name sortKey="Wen, B" uniqKey="Wen B">B Wen</name></author><author><name sortKey="Wang, H" uniqKey="Wang H">H Wang</name></author><author><name sortKey="Meng, X" uniqKey="Meng X">X Meng</name></author><author><name sortKey="Lan, J" uniqKey="Lan J">J Lan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tang, Xc" uniqKey="Tang X">XC Tang</name></author><author><name sortKey="Agnihothram, Ss" uniqKey="Agnihothram S">SS Agnihothram</name></author><author><name sortKey="Jiao, Y" uniqKey="Jiao Y">Y Jiao</name></author><author><name sortKey="Stanhope, J" uniqKey="Stanhope J">J Stanhope</name></author><author><name sortKey="Graham, Rl" uniqKey="Graham R">RL Graham</name></author><author><name sortKey="Peterson, Ec" uniqKey="Peterson E">EC Peterson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pallesen, J" uniqKey="Pallesen J">J Pallesen</name></author><author><name sortKey="Wang, N" uniqKey="Wang N">N Wang</name></author><author><name sortKey="Corbett, Ks" uniqKey="Corbett K">KS Corbett</name></author><author><name sortKey="Wrapp, D" uniqKey="Wrapp D">D Wrapp</name></author><author><name sortKey="Kirchdoerfer, Rn" uniqKey="Kirchdoerfer R">RN Kirchdoerfer</name></author><author><name sortKey="Turner, Hl" uniqKey="Turner H">HL Turner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Drosten, C" uniqKey="Drosten C">C Drosten</name></author><author><name sortKey="Seilmaier, M" uniqKey="Seilmaier M">M Seilmaier</name></author><author><name sortKey="Corman, Vm" uniqKey="Corman V">VM Corman</name></author><author><name sortKey="Hartmann, W" uniqKey="Hartmann W">W Hartmann</name></author><author><name sortKey="Scheible, G" uniqKey="Scheible G">G Scheible</name></author><author><name sortKey="Sack, S" uniqKey="Sack S">S Sack</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zens, Kd" uniqKey="Zens K">KD Zens</name></author><author><name sortKey="Chen, Jk" uniqKey="Chen J">JK Chen</name></author><author><name sortKey="Farber, Dl" uniqKey="Farber D">DL Farber</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Corée du Sud</li></country><region><li>Région capitale de Séoul</li></region><settlement><li>Séoul</li></settlement></list><tree><country name="Corée du Sud"><region name="Région capitale de Séoul"><name sortKey="Kim, Myung Hee" sort="Kim, Myung Hee" uniqKey="Kim M" first="Myung Hee" last="Kim">Myung Hee Kim</name></region><name sortKey="Chang, Jun" sort="Chang, Jun" uniqKey="Chang J" first="Jun" last="Chang">Jun Chang</name><name sortKey="Kim, Hyun Jik" sort="Kim, Hyun Jik" uniqKey="Kim H" first="Hyun Jik" last="Kim">Hyun Jik Kim</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:31329652" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a MersV1
| This area was generated with Dilib version V0.6.33. |  |